Two investigators independently screened the citations and reviewed the full texts for eligible studies according to a predefined form. The outcomes of interest were post-intervention AKI rate and renal replacement therapy (RRT) rate. Methodsįrom inception to May 13, 2022, we searched Ovid Medline, EMBASE, Cochrane Library, SCOPUS,, and WHO ICTRP for RCTs comparing higher BP target versus normotension in hemodynamically unstable patients (shock, post-cardiac arrest, or surgery patients). We conducted a systematic review and meta-analysis of available randomized clinical trial (RCT) results to address this knowledge gap. An optimal blood pressure (BP) target to prevent AKI remains undetermined. Renal hypoperfusion is one of the most common causes of acute kidney injury (AKI), especially in shock and perioperative patients.
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